One of my greatest fears in starting a business was that I would unwittingly slip into that same mentality. So when I started Blue Orchid Designs, one of my main priorities was to remain involved in philanthropic and humanitarian efforts.
There are a lot of great causes out there and there is no possible way we can each be involved in all of them. The key is to support causes that align with your personal passions. The issues of HIV/AIDS and cancer, human rights, and debilitating poverty are areas that resonate deeply with my heart. Here are some great organizations whose work focuses on those issues:

Pink Initiative
Pink Initiative is a collection of wedding industry professionals and private donors dedicated to funding awareness, outreach, education and research for breast cancer.

Thirst Relief International
From the website:
"Thirst Relief International, in partnership with you, exists to provide humanitarian and disaster relief to those in need worldwide through the provision of safe, clean drinking water. We are sickened and called to action knowing that nearly 2 million people die annually (90% of which are children under the age of 5) simply because they lack access to clean drinking water. As a result, we are working to put an end to the worldwide water crisis plaguing 1.1 billion people."

Kiva: Loans that Change Lives
From the website:
"Kiva.org allows individuals to make $25 loans to low-income entrepreneurs in the developing world (microfinance). By doing so, individuals like you provide affordable working capital for the poor (money to buy a sewing machine, livestock, etc.), empowering them to earn their way out of poverty. It's a new, direct and sustainable way to fight global poverty."
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I love Kiva! It is a fantastic organization. I have already been repaid on several loans I made in November. It is fun to put that money back into a loan for another deserving business person.